Page 14 - Advances in Forensic Applications of Mass Spectrometry - Jehuda Yinon

1522_C01.fm Page 1 Tuesday, December 2, 2003 10:05 AM

Screening for Drugs
in Body Fluids by 1

GC/MS

HANS H. MAURER

Contents
1.1 Introduction
1.1.1 Matrices for Drug Screening
1.1.2 Sample Preparation
1.2 Screening for Drugs in Blood, Serum, or Plasma by GC/MS
1.3 Screening for Drugs in Alternative Matrices by GC/MS
1.4 Screening for Drugs in Urine by GC/MS
1.4.1 Screening Procedures for Detection of Particular Drug
Classes in Urine by GC/MS
1.4.1.1 Screening Procedures for Detection of Particular
Drug Classes of Basic or Neutral Drugs and/or
Their Metabolites in Urine
1.4.1.2 Screening Procedures for Detection of Particular
Drug Classes of Acidic Drugs and/or Their
Metabolites in Urine
1.4.2 General Screening Procedures for Simultaneous Detection
of Several Drug Classes in Urine by GC/MS
1.4.2.1 General Screening Procedure for Drug Classes
Relevant in Doping after Enzymatic Hydrolysis,
SPE, and Combined TMS and TFA
Derivatization
1.4.2.2 General Screening for Most of the Basic and
Neutral Drug Classes in Urine after Acid
Hydrolysis, LLE, and AC
1.4.2.3 General Screening Procedures for Simultaneous
Detection of Several Classes of Acidic Drugs in
Urine after Extractive Methylation
1.5 Conclusions and Perspectives
Acknowledgments
References

© 2004 by CRC Press LLC