Page 146 - Advances in Forensic Applications of Mass Spectrometry - Jehuda Yinon

1522_C03.fm Page 129 Thursday, November 13, 2003 9:53 AM

Substance Abuse in
Sports: Detection of 3

Doping Agents in
Hair by Mass

Spectrometry

MARION VILLAIN
VINCENT CIRIMELE
PASCAL KINTZ

Contents

3.1 Introduction
3.2 Procedures
3.2.1 Specimen Collection
3.2.2 Decontamination Procedures
3.3 Analysis of Doping Agents
3.3.1 Detection of Anabolic Steroids
3.3.2 Detection of Corticosteroids
3.3.3 Detection of b-Adrenergic Stimulants
3.4 Discussion
3.5 Conclusions
References

3.1 Introduction

It is generally accepted that chemical testing of biological fluids is the most
objective means of diagnosis of drug use. The presence of a drug analyte in
a biological specimen can be used as evidence of recent exposure. The stan-
dard in drug testing is immunoassay screening, followed by gas chromato-
graphic–mass spectrometric (GC/MS) confirmation conducted on a urine
sample. More recently, a variety of body specimens other than urine, such
as saliva, sweat, meconium, or hair have been proposed to document drug
exposure.

© 2004 by CRC Press LLC