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Such quantification procedures must be fully validated according to inter-
national guidelines. 47
Finally, LC/MS has shown to be an ideal supplement, especially for more
polar, unstable, or low-dosed drugs.
Acknowledgments
The author would like to thank his coworkers Thomas Kraemer, Carsten
Kratzsch, Frank T. Peters, Dietmar Springer, Roland F. Staack, and Armin A.
Weber for their support.
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