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                             Such quantification procedures must be fully validated according to inter-
                             national guidelines. 47
                                Finally, LC/MS has shown to be an ideal supplement, especially for more
                             polar, unstable, or low-dosed drugs.


                             Acknowledgments

                             The author would like to thank his coworkers Thomas Kraemer, Carsten
                             Kratzsch, Frank T. Peters, Dietmar Springer, Roland F. Staack, and Armin A.
                             Weber for their support.


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