Page 75 - Advances in Forensic Applications of Mass Spectrometry - Jehuda Yinon

1522_C02.fm Page 63 Wednesday, November 12, 2003 9:36 AM

Liquid

Chromatography/Mass 2
Spectrometry in Forensic

Toxicology

MACIEJ J. BOGUSZ

Contents
2.1 Introduction
2.2 Methodical Considerations Relevant to Forensic Analysis
2.2.1 Separation Issues
2.2.1.1 Sample Pretreatment Methods and
Matrix Suppression
2.2.1.2 Composition of the Mobile Phase and Type
of Column
2.2.2 Detection Issues
2.2.2.1 Choice of Ionization Source
2.2.2.2 Choice of Mass Analyzer (Q vs. QQQ vs. IT
vs. qTOF)
2.3 LC/MS Analysis of Illicit Drugs
2.3.1 Opiate Agonists
2.3.1.1 Analysis of Street Drugs
2.3.1.2 Analysis of Biological Fluids
2.3.2 Amphetamine and Ecstasy
2.3.2.1 Analysis of Biological Fluids
2.3.2.2 Analysis of Alternative Samples
2.3.3 Cocaine
2.3.3.1 Analysis of Biological Fluids
2.3.3.2 Analysis of Alternative Samples
2.3.3.3 Prenatal Exposure to Cocaine
2.3.4 Cannabis
2.3.4.1 Analysis of Street Drugs
2.3.4.2 Analysis of Biological Fluids
2.3.5 Hallucinogens
2.3.5.1 LSD
2.3.5.2 Other Hallucinogens

© 2004 by CRC Press LLC