Page 6 - Catalysts for Fine Chemical Synthesis Vol 1 - Robert & Poignant

Contents

Series Preface . . . . . . . . . . . . . . . . . . . . xiii

Preface to Volume 1 . . . . . . . . . . . . . . . . . . xv

Abbreviations . . . . . . . . . . . . . . . . . . . . xvii

ev
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Part I: Review . . . . . . . . . . . . . . . . . . . 1
R
I:
1 The Integration of Biotransformations into the
Catalyst Portfolio . . . . . . . . . . . . . . . . . 3
1.1 Hydrolysis of esters, amides, nitriles and
oxiranes . . . . . . . . . . . . . . . . . . . . 4
1.2 Reduction reactions . . . . . . . . . . . . . . . . 9
1.2.1 Reduction of carbonyl compounds . . . . . . . 10
1.2.2 Reduction of alkenes . . . . . . . . . . . . 13
1.3 Oxidative transformations . . . . . . . . . . . . . 17
1.4 Carbon±carbon bond-forming reactions . . . . . . . . 26
1.5 Conclusions . . . . . . . . . . . . . . . . . . . 37
References . . . . . . . . . . . . . . . . . . . . . 39

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II:
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Part II: Procedures . . . . . . . . . . . . . . . . . . 47
2 General Information. . . . . . . . . . . . . . . . . 49
3 Asymmetric Epoxidation . . . . . . . . . . . . . . . 51
3.1 Introduction. . . . . . . . . . . . . . . . . . . 51
References . . . . . . . . . . . . . . . . . . . . . 52
4 Epoxidation of a, b-Unsaturated Carbonyl Compounds . . . . 55
4.1 Non-asymmetric epoxidation . . . . . . . . . . . . 55
4.2 Asymmetric epoxidation using poly-d-leucine . . . . . . 56
4.2.1 Synthesis of leucine N-carboxyanhydride . . . . . 57
4.2.2 Synthesis of immobilized poly-d-leucine . . . . . 58