Page 198 - Color Atlas of Biochemistry

Nucleotide Metabolism 189

A. Components of nucleobases

Glu 4 Fumarate HCO 3 NH 3 Glycine
C H C
2
3 5 2g 2f
N C
[NH ] 2h [NH ] COO
2
2
C C 6 2b
Gln 1a 2 6 Asp 7
N C 5 N THF
1 C
1 N
THF C [CHO] 2c
1 C C 8
[CHO] 2 N OHC
HCO 3 N 4
OOC 2i 3 9 N 10 THF
CH CHO
2
N 10
2
2
C THF [NH ] [NH ]
H N H COO
3
Aspartate Gln Glu Gln Glu
Pyrimidine Purine 2d 2a

B. Pyrimidine and purine synthesis

[NH ] Carbamoyl Phosphoribosyl P R P P C
2
N phosphate diphosphate
N C C
C N C
1a O P C C N C
N C N C C C C C
C N C
N
1b C C 1c C C 1d 1e 1f
HCO 3 C C N C N C P R P R
C N-Carbamoyl Dihydro- Orotate 5'-mono- Uridine 5'-mono-
N C
aspartate orotate phosphate phosphate (UMP)
Aspartate
5' UMP O
1. Pyrimidines P O CH 2
O C
1' HN CH
Phosphoribosyl P R = H H
diphosphate H H O C N CH
P R P P N
C OH OH P O CH 2
2a C O
Glycine 5'-Phosphoribosyl residue
H H
H H
N N N N
C C C
C C OH OH
P R
2b C 2c C 2d C
N N N
N
P R P R P R IMP O
C N
HN C
C N C N C N C N CH
C N C N C N C HC C
C C C C N N
2e, N C N 2g, N C N 2i C N C N 2j C N C N P O CH 2
2f 2h O
P R P R P R P R
H H
Inosine 5'-mono- H H
phosphate (IMP)
2. Purines OH OH

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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