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80  Chapter 4 Process Synthesis and Design Optimization
                 and examples include: conversion from gas phase to liquid phase reactions;
                 improved catalyst systems; combinations of reaction; and separation such as a zeo-
                 lite membrane reactor or reactive distillation. New reactor configurations, such as:
                 switching from packed bed to fluidized bed system (Dutta and Gualy, 1999) or a
                 homogeneous system, reverse-flow reactor systems (van de Beld and Westerterp,
                 1996); interstage component removal (Westerterp et al., 1989); development of a
                 bubble column reactors (Schluter et al., 1992) are all improvements that have been
                 explored. The results of this research are configured in reactor models. Improve-
                 ments in separation are also often subject to detailed research activities. On examin-
                 ing developments at the grass-roots level it should be mentioned that these also
                 focus on a particular catalyst system and configuration. The results of such research
                 activity are included in what is called ªfeasible flowsheet modelsº. Before the concep-
                 tual design with its synthesis study of a project is started, the results of research will
                 be evaluated in the context of other process routes in a feasibility study.
                  The alternative options for the sequencing of separations will remain, but many
                 processes have a limited number of separations, or have constraints which limit
                 freedom with regard to the number of options available.
                  The limitations in technical knowledge and the constraints justifies the conclu-
                 sion that improvements to an existing system or a grass-roots design often have lim-
                 ited practical alternatives to be introduced into a (preferably fundamental) model.
                The number of alternatives is also restricted due too the application of the layered
                 approach-if this approach isn't applied the number would increase tremendously,
                 this is at best be reflected in a decision Figure 4.5. The limited number of alterna-
                 tives, and the ease of their simulation and overall design, makes the comparison of
                 alternatives on a direct, economic basis and the avoidance of large optimization
                 problems an attractive proposition. This does not mean that broad studies are not
                 carried out. Indeed, one benefit of a broad study is the identification of opportunities
                 for further developments. In the context of sustainability, a search for cheaper routes
                 by increasing knowledge and solving constraints will undoubtedly gather interest.

                 4.1.4
                 Economic Calculations

                 Economics ultimately determine whether a process will be executed, and a number
                 of factors play an important role in achieving an objective, optimal design:
                   .  An economic evaluator and a professional cost estimator should be involved
                      in the design team to ensure objectivity in the cost estimates and evaluations
                   .  The cost estimator is responsible for updating estimation data for the specific
                      location in the database used for the evaluation and optimization of process
                      design alternatives as part of the simulator. Discontinuities in the cost data
                      set for equipment must be smoothed in order to avoid converging problems
                      during optimization.
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