Page 12 - Handbook of Hazardous Chemical Properties

2 ACETIC ANHYDRIDE
causes coughing, chest pains, and irritation of the nose and throat; may cause nausea and vomiting.
Contact with skin and eyes causes burns; General Treatment for Exposure: INHALATION: Move the
victim immediately to fresh air. If breathing becomes difficult, give oxygen and get medical attention
immediately. INGESTION: If the victim is conscious, have him drink water or milk. Do not induce
vomiting. SKIN OR EYE CONTACT: Flush immediately with lots of clean running water; wash eyes
for at least 15 min. and get medical attention as quickly as possible; remove contaminated clothing;
Toxicity by Inhalation (Threshold Limit Value): 10 ppm; Short-Term Exposure Limits: 40 ppm for 5
rnin.; Toxicity by Ingestion: LD,, 0.5 to 5.0 gkg (rat); Late Toxicity: No data; Vqor (Gas) Irritant
Characteristics: Vapors cause moderate irritation such that workers will find high concentrations very
unpleasant. Effects are temporary; Liquid or Solid Irritant Characteristics: This is a fairly severe skin
irritant; may cause pain and secondary burns after a few minutes of contact; Odor 27zreshold 1 .O ppm.
Fire Hazards - Flash Point (deg. F): 112 OC; 104 CC; Flammable Limits in Air (96): 5.4 - 16.0; Fire
Extinguishing Agents: Water, alcohol foam, dry chemical or carbon dioxide; Fire Edingziishing Agents
Not To Be Used None; Special Hazards of Combustion Products: Irritating vapors produced when
heated; Behavior in Fire: Not Pertinent; Ignition Temperature (deg. F): 800; Electrical Hazard Not
Pertinent; Burning Rate: 1.6 dmin.
Chemical Reactivity - Reactivity with Water: No reaction; Reactivity with Common Materials:
Corrosive, particularly when diluted. Attacks most common metals, including most stainless steels.
Excellent solvent for many synthetic resins or rubber; Stability During Tramport: Stable; Neutralizing
Agents for Acids and Caustics: Dilute with water, rinse with sodium bicarbonate solution;
Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

ACETIC ANHYDRIDE
Chemical Designations - Synonyms: Ethanoic Anhydride; Chemical Fomla: CH,CO-0-COCH,.
Observable Characteristics - Physical State (as normally shipped): Liquid; Color: Colorless; Odor:
Very strong; pungent; vinegar-like characteristic odor.
Physical and Chemical Properties - Physical State at I5 "c and 1 uhn. : Liquid; Molecular Weight:
102.09; Boiling Point at I atm.: 282, 139, 412; Freezing Point: -101, -74.1, 199.1; Critical
Temperature: 565, 296, 569; Critical Pressure: 679, 46.2, 4.68; Spec@c Gravity: 1.08 at 20 "C
(liquid); Vqor (Gas) Density: Not pertinent; Ratio ofSpeci@c Heats of Vapor (Gas): 1.093; Latent
Heat of Vaporization: 119, 66.2, 2.77; Heat of Combustion: -7058, -3921, -164.2; Heat of
Decomposition: Not pertinent.
Health Hazards Information - Recommended Personal Protective Equipment: Protective clothing
when skin contact might occur; respiratory protection is necessary for all exposures; complete eye
protection is recommended; Symptoms Following Exposure: Liquid is volatile and causes little irritation
on unprotected skin. However, causes severe burns when cloning is wet with the chemical, or if it
enters gloves or shoes; causes skin and eye burns and irritation of the respiratory tract. Nausea and
vomiting may develop after exposure; General Treament for Exposure: INHALATION: Move the
victim immediately to fresh air; if breathing becomes difficult, give oxygen, and seek medical attention
immediately. INGESTION: Do not induce vomiting. SKIN OR EYE CONTACT WITH LIQUID OR
VAPOR: Flush immediately with clean, running water; wash eyes for at least 15 minutes; seek medical
attention immediately; Taxiciry by Inhalation (Threshold Limit Value): 5 ppm; Short-Tern Exposure
Limits: No data found; Toxicity by Ingestion: 0.5 to 5.0 g/kg (rat); Late Taxicity: Not pertinent; Vapor
(Gas) Irritant Characteristics: Vapor is moderately irritating such that personnel will not usually
tolerate moderate or high concentrations; Liquid or Solid Irritant Characteristics: Fairly severe skin
irritant; may cause pain and second degree burns; burns skin after a few minutes of contact; Odor
ThreshoM: 0.14 ppm.
Fire Hazards - Flash Point (deg. F): 136 OC; 120 CC; Flammablefirnits in Air (96): 2.7 - 10.0; Fire
Extinguishing Agents: Water spray, dry chemical, alcohol foam, or carbon dioxide; Fire Extinguishing
Agents Not To Be Used Water and foam react, but heat liberated is not enough to create a hazard. Dry
chemical forced below the surface can cause foaming and boiling; Special Hazards of Combustion
Products: Irritating vapors generated upon heating; Behavior in Fire: Not pertinent; Ignition