Page 369 - Industrial Ventilation Design Guidebook

324 CHAPTER 5 PHYSIOLOGICAL AND TOXICOLOGICAL CONSIDERATIONS

FIGURE 5.53 Relationship between the concentration of toluene in front of a gravure press and
the consumption of toluene. 195

habits and height, which can affect exposure. In biological monitoring, factors
such as physical activity, i.e., cardiac output and minute volume of ventilation,
metabolism, and the mass of depot tissues (e.g., adipose tissue) may also be
66 67
considered. ' Figure 5.54 depicts the difference between occupational hy-
giene and biological monitoring.

FM5URE 5.54 The Idea of biomonitoring compared to the concept of occupational/ environmental
hygienic monitoring. Hygienic monitoring (I) means measurement of concentration of a compound or a fee-
tor (e.g., fungal spores) outside the organism, e.g., air monitoring. Biomonitoring (2) means measurement of a
compound or its metabolites within the organism, for example in the blood, urine, or exhaled air, measure-
ment of binding products in the blood or urine or assessment of an existing effect such as chromosomal or
DNA damage in white blood cells. 151