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P r o c e s s I n t e g r a t i o n  13


                     (Linnhoff et al., 1982; Linnhoff et al., 1994; Shenoy, 1995; Smith, 2005;
                     El-Halwagi, 2006; Kemp 2007; Klemeš, Smith, and Kim, 2008).
                        One of the first works in this field was Hohmann’s (1971) PhD
                     thesis, which introduced a systematic thermodynamics-based
                     reasoning for evaluating the minimum energy requirements for a
                     given HEN synthesis problem. In the late 1970s this work was
                     continued by Linnhoff and Flower, who used Hohmann’s foundation
                     to develop the basis of Pinch Technology—now considered the
                     cornerstone of HI. As is often the case with a pioneering innovation,
                     this work was difficult to publish. Yet the authors’ strong commitment
                     eventually led to the publication of their ideas in Linnhoff and
                     Flower (1978), which has since become the most cited paper in the
                     history of chemical engineering. Similar work (Umeda et al., 1978;
                     Umeda, Harada, and Shiroko, 1979) was independently published in
                     Japan, but it was Linnhoff (supported by teams from UMIST and
                     later Linnhoff March Ltd.) who pushed the new concept through
                     academia and industry. The publication of the first “red” book by
                     Linnhoff et al. (1982) played a key role in the dissemination of HI
                     methodology. This user’s guide to Pinch Analysis detailed the most
                     common process network design problems, including HEN synthesis,
                     heat recovery targeting, and selecting multiple utilities.
                        These methodologies were developed and pioneered by the
                     Department of Process Integration, UMIST (now the Centre for
                     Process Integration, CEAS, the University of Manchester) in the late
                     1980s and 1990s (Linnhoff et al., 1982; Linnhoff and Vredeveld, 1984;
                     Linnhoff et al., 1994; Klemeš et al., 1997; Smith et al., 2000; Smith,
                     2005). A second edition of Linnhoff’s user’s guide was published by
                     Kemp (2007). Applications of HI in the food industry were presented
                     in Klemeš and Perry (2007a) and in Klemeš, Smith, and Kim (2008).
                     Tan and Foo (2007) successfully applied the Pinch Analysis approach
                     to carbon-constrained planning for the energy sector, and Foo, Tan,
                     and Ng (2008) applied the cascade analysis technique to carbon-
                     footprint-constrained energy planning.
                        Another important part in process design and optimization is
                     the synthesis phase of process flowsheets. From the earliest stages of
                     PI there have been attempts to combine it with optimization (see, e.g.,
                     Giammatei, 1994). Such combining is usually performed after the
                     targeting phase mentioned previously. Ideally, the structure of the
                     entire process—and the configurations of the operating units within
                     it—should be simultaneously designed and optimized, because the
                     performance of each unit influences the others. The main source of
                     complexity in this synthesis is the problem’s dual nature of being
                     both continuous and discrete. There are several known methods for
                     performing the task, including heuristic, evolutionary, and
                     superstructure-based approaches. Two major classes of methods for
                     process synthesis are heuristic and algorithmic (or Mathematical
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