Page 179 - The Memory Program How to Prevent Memory Loss and Enhance Memory Power

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CHAPTER 18

Medications That Stimulate Brain Function

PHOSPHATIDYLSERINE, HYDERGINE, and nootropics act via brain mechanisms other than
acetylcholine.

Phosphatidylserine (PS) for Age-Related Memory Loss

Phosphatidylserine is a naturally occurring substance that is chemically similar to
phosphatidylcholine, which is the active promemory ingredient in lecithin. But what is the basis for
its use, and where does it fit into your memory program?

Physiologic Actions of Phosphatidylserine

Phosphatidylserine is present in the membrane that surrounds each cell, and it can alter the
fluidity and functional state of these cell membranes. Stabilizing cell membranes may shield the
nerve cell from injury and death.
Phosphatidylserine indirectly increases the production and release of several neurotransmitters,
including epinephrine, norepinephrine, serotonin, and dopamine. These neurotransmitters,
especially norepinephrine and dopamine, are known to improve attention, concentration, and
alertness.
In aged mice, phosphatidylserine prevents, and partly reverses, age-related neurochemical
changes. Mice receiving this com-