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XII Contents
17.3.6 Biomedical Applications of Sialoconjugate Arrays 388
17.4 Conclusions 388
Acknowledgments 389
References 389
18 Methyltransferases in Biocatalysis 393
Ludger Wessjohann, Martin Dippe, Martin Tengg, and Mandana
Gruber-Khadjawi
18.1 Introduction 393
18.2 SAM-Dependent Methyltransferases 395
18.2.1 Substrates 396
18.2.2 Cofactors 400
18.2.3 Higher Homologs and Derivatives of SAM 403
18.2.4 Cofactor (Re)Generation 406
18.2.5 Cascade Applications 410
18.3 Conclusion and Outlook 415
Abbreviations 417
Acknowledgement 417
References 418
19 Chemoenzymatic Multistep One-Pot Processes 427
Harald Gr¨oger and Werner Hummel
19.1 Introduction: Why Chemoenzymatic Cascades and Why One-Pot
Processes? 427
19.2 Concepts of Chemoenzymatic Processes 427
19.3 Combination of Substrate Isomerization and their Derivatization with
Chemo- and Biocatalysts Resulting in Dynamic Kinetic Resolutions
and Related Processes 429
19.4 Combination of Substrate Synthesis (Without Isomerization) and
Derivatization Step(s) 438
19.4.1 One-Pot Processes with an Initial Biocatalytic Step, Followed by
Chemocatalysis or a Noncatalyzed Chemical Process 439
19.4.2 One-Pot Process with an Initial Chemo Process, Followed by
Biocatalysis 443
19.4.2.1 Combination of Noncatalyzed Organic Reactions and
Biocatalysis 443
19.4.2.2 Combination of Metal Catalysis and Biocatalysis 445
19.4.2.3 Combination of Organocatalysis and Biocatalysis 449
19.5 Conclusion and Outlook 453
References 453
Index 457
