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68 3 Microbial Synthesis of Biodegradable Polyesters: Processes, Products, Applications

4. Hezayen, F.F., Tindall, B.J., Steinbüchel, the transcriptional repressor PhaR in
A., and Rehm, B.H.A. (2002) Character- Ralstonia eutropha H16. Microbiology,
ization of a novel halophilic archaeon, 151, 825–833.
Halobiforma haloterrestris gen. nov., 14. Steinbüchel, A., Aerts, K., Babel, W.,
sp. nov., and transfer of Natronobac- Follner, C., Liebergesell, M., Madkour,
terium nitratireducens to Halobiforma M.H., Mayer, F., Pieper-Fürst, U., Pries,
nitratireducens comb. nov. Int. J. Syst. A., Valentin, H.E., and Wieczorek, R.
Evol. Microbiol., 52, 2271–2280. (1995) Considerations on the structure
5. Hoffmann, N. and Rehm, B.H.A. and biochemistry of bacterial polyhy-
(2005) Nitrogendependent regulation droxyalkanoic acid inclusions. Can. J.
of medium-chain length polyhy- Microbiol., 41, 94–105.
droxyalkanoate biosynthesis genes in 15. Rehm, B.H.A. (2003) Polyester synthases:
pseudomonads. Biotechnol. Lett., 27, natural catalysts for plastics. Biochem. J.,
279–282. 376, 15–33.
6. Lee, S.Y. and Chang, H.N. (1995) Pro- 16. Rehm, B.H.A. and Steinbüchel, A. (1999)
duction of poly(hydroxyalkanoic acid). Biochemical and genetic analysis of
Adv. Biochem. Eng./Biotechnol., 52, PHA synthases and other proteins
27–58. required for PHA synthesis. Int. J. Biol.
7. Gao, D., Maehara, A., Yamane, T., and Macromol., 5, 3–19.
Ueda, S. (2001) Identification of the 17. Rehm, B.H.A. (2007) Biogenesis of
intracellular polyhydroxyalkanoate Microbial Polyhydroxyalkanoate Gran-
depolymerase gene of Paracoccus deni- ules: a platform technology for the
trificans and some properties of the gene production of tailor-made bioparticles.
product. FEMS Microbiol. Lett., 196, Curr.IssuesMol.Biol., 9, 41–62.
159–164. 18. Brandl, H., Gross, R.A., Lenz, R.W.,
8. Handrick, R., Reinhardt, S., and and Fuller, R.C. (1990) Plastics from
Jendrossek, D. (2000) Mobilization of bacteria and for bacteria: poly(beta-
poly(3-hydroxybutyrate) in Ralstonia hydroxyalkanoates) as natural, biocom-
eutropha. J. Bacteriol., 20, 5916–5918. patible, and biodegradable polyesters.
9. Rehm, B.H.A. (2006) Genetics and Adv. Biochem. Eng. Biotechnol., 41,
biochemistry of polyhydroxyalkanoate 77–93.
granule self-assembly: the key role of 19. Lee, S.Y. and Choi, J.I. (2001) Production
polyester synthases. Biotechnol. Lett., 28, of microbial polyester by fermentation
207–213. of recombinant microorganisms. Adv.
10. Zinn, M., Witholt, B., and Egli, T. (2001) Biochem. Eng. Biotechnol., 71, 183–207.
Occurrence, synthesis and medical appli- 20. Brockelbank, J.A., Peters, V., and Rehm,
cation of bacterial polyhydroxyalkanoate. B.H.A. (2006) Recombinant Escherichia
Adv. Drug Delivery Rev., 53, 5–21. coli produces ZZ domain displaying
11. Peoples, O.P. and Sinskey, A. (1989) biopolyester granules suitable for IgG
Poly-betahydroxybutyrate (PHB) biosyn- purification. Appl. Environ. Microbiol.,
thesis in Alcaligenes eutrophus H16. 72, 7394–7397.
Identification and characterization of the 21. Peters, V. and Rehm, B.H.A. (2006) In
PHB polymerase gene (phbC). J. Biol. vivo enzyme immobilization by use of
Chem., 264, 15298–15303. engineered polyhydroxyalkanoate syn-
12. Slater, S.C., Voige, W.H., and Dennis, thase. Appl. Environ. Microbiol., 72,
D.E. (1988) Cloning and expression in 1777–1783.
Escherichia coli of the Alcaligenes eutro- 22. Rehm, B.H.A. (2006) in Microbial Bio-
phus H16 poly-beta-hydroxybutyrate nanotechnology: Biological Self-Assembly
biosynthetic pathway. J. Bacteriol., 170, Systems and Biopolymer-based Nanos-
4431–4436. tructures (ed B.H.A. Rehm), Horizon
13. Pötter, M., Müller, H., and Steinbüchel, Bioscience, Cambridge, pp. 1–34.
A. (2005) Influence of homologous 23. Barnard, G.C., McCool, J.D., Wood,
phasins (PhaP) on PHA accumulation D.W., and Gerngross, T.U. (2005) Inte-
and regulation of their expression by grated recombinant protein expression