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62    Biofuels for a More Sustainable Future


          implications for human health (Gerbens-Leenes et al., 2009). Therefore, to
          answer to the need of assessing the interplay between the different sectoral
          demands and identifying win-win strategy of global resources management,
          the nexus concept among food, energy, water, land use, and ecosystems has
          been proposed (Ringler et al., 2013).
             Karabulut et al. (2018) suggested a matrix for the operationalization of
          nexus assessment toward the identification of the main interlinkages
          between the different resources and proposed a theoretical framework for
          integrating nexus and LCA.
             Studies applying the nexus concept to biofuels are often focusing on
          emerging economies, where the magnitude of impact will vary significantly
          across regions and countries depending on the size of the biofuel targets
          adopted, the identified technologies and feedstock, and especially the
          water availability and scarcity level (see, e.g., Silalertruksa and Gheewala,
          2019). Optimization of biofuels production systems may profit from a
          nexus approach. For example, a biorefining system could be designed
          ensuring that the interactions with the surrounding watershed are
          taken into account, and the supply chain for the production and distri-
          bution of feedstocks, grains, and biofuels is compatible with local water
          and land requirements (Lo ´pez-Dı ´az et al., 2018). Recently, the assessment
          of nexus has been coupled with input-output matrixes (Bellezoni et al.,
          2018) for assessing possible consequences of future scenarios of biofuels
          expansion.
             From the modeling point of view, several challenges are in common to
          food and biofuel assessment (Sala et al., 2017) whereas others are specific of
          feedstocks for bio-based products (Mirabella et al., 2013).

          4.5 Closing the loop: A circular bioeconomy to foster the use of
          sustainable feedstocks
          Both international and European policies are advocating a transition toward
          “bioeconomy,” an economy aiming at reducing the dependence from
          fossil-based resources, limiting greenhouse gas emissions, safeguarding food
          security, and ensuring a sustainable economic growth. Besides, circular
          economy policies are aiming at closing loop of resources as much as possible.
          Increasingly, studies are performed to assess sustainability of bio-based
          alternatives, starting from energy applications up to materials and products
          (e.g., Mirabella et al., 2013). In fact, the application of circular economy
          principles to bioeconomy could represent a valuable contribution to bio-
          economy performance optimization (Corrado and Sala, 2018). However,
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