Page 327 - Chiral Separation Techniques

320 13 International Regulation of Chiral Drugs

Methylphenobarbitone R-isomer is cleared more rapidly in young males than young females or elderly of either sex poor metabolizers deficient in enzyme CYP 2D6 have lower proportion of the active S-isomer when racemate is

Examples 1 sedative Metoprolol antihypertensive administered

Type of effect Gender Genetic factors 1 These examples have been taken from the reviews cited in the text.