Page 124 - Color Atlas of Biochemistry

Metabolic Regulation 115

A. Fundamental mechanisms of metabolic regulation

Transcriptional Induction Repression
control
R
Gene

H RP RP H
Transcription
1
RP RP

Regulator
mRNA
protein

A Translation Z

Interconversion
Hormone
H
Key enzyme
(inactive)

A P
PP P
2
Second E E Inactivated
messenger 1 2 enzyme

Activated A
enzyme P P

Modulation
by ligands
End product

Key enzyme
A A B (active) P C Z

6
Meta-
bolic
pathway
Coenzyme Coenzyme Feedback
inhibition
3

Availability pre- Competition Regeneration
cursors, com- for substrates of the coenzyme
partmentation or coenzymes 5
4

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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