Page 130 - Color Atlas of Biochemistry

Metabolic Regulation 121

A. Principles of hormone action
H H
Lipophilic Hydrophilic
hormones hormones
H

Receptor
Receptor
H

DNA H H
Tran- Second messenger
scription
mRNA
Polysome

Translation

Cell response Cell response
Protein

B. Hormonal regulation of glucose metabolism in the liver

Gene 1 Gene 2 Gene 3

Hormone Transcription
receptor
complex mRNA 1 mRNA 2 mRNA 3

Translation
Cortisol Gluco-
corticoid Enzyme 1 Enzyme 2 Enzyme 3
receptor

Glu- Glucose Glc-6- Amino
cose P acids
Gluconeogenesis

ATP cAMP AMP
Adenylate
cyclase
PDE
Glc-1- P GSK-3
PKA

PI K
3
P P
Gα
I
IRS P

Glycogen
Glucagon PP PP
receptor
Glycogen Glycogen Insulin
phosphorylase synthase receptor
Glucagon Insulin

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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