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Protein Metabolism         175


                 A. Protein metabolism: overview



                                                Functional
                                                proteins
                                                  10 000 g
                          Maturation                                      Marking





                                                    Protein synthesis (300–400 g/day)  Proteolysis  (300–400 g/day)  Proteasome  Degradation
                                Sugars






                  Folding











                                                                                    Peptide       Lysosome

                         Translation                                      Degradation




                                               Amino acid pool

                                                    100 g
                                                                       Excess
                                                                       amino
                                                                       acids
                               Protein
                   Food        secretion                                            Glucose        Lipids
                 50–100 g/day  50 g/day
                                                 De-novo
                                 Resorption      synthesis       Degradation
                               Up to 150 g/day    As required    50–100 g/day


                                                                                      2-Oxo-      Ketone
                                                                                      acids       bodies
                 Digestion


                                                                                                 A
                                            Pyruvate                    NH 3                         PP P
                   Amino                    Phosphoenolpyruvate
                   acids                                                                           ATP
                                            3-Phosphoglycerate
                                            2-Oxoacids
                                                                                       2
                                                                                          2
                                            Sugar phosphates           Urea         CO , H O
                Intestine

                 10g/day                                                        Kidney





           Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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