Page 190 - Color Atlas of Biochemistry

Protein Metabolism 181

A. Amino acid degradation: overview

Several Alanine Threonine
pathways
Glucose

Cysteine Pyruvate Serine Glycine

Asparagine
Acetyl Aceto-
CoA acetate
Aspartate
Oxalo- Ketone
acetate body
Phenyl-
alanine

Pyruvate
Fuma- Tricarboxylic
Tyrosine
rate acid cycle Leucine Lysine

Iso-
leucine Succinyl 2-Oxo- Tryptophan Alanine
glutarate
CoA
Valine

Acetyl
CoA Glutamate Histidine

Propionyl Glutamine Proline
CoA

Pyruvate Cysteine Methionine

Serine Arginine

Glucogenic Transamination Hydrolytic deamination
Glucogenic
Ketogenic and ketogenic Oxidative deamination Eliminating deamination

B. Deamination

COO NADH+H NAD COO COO
O C N A NH 4 N A H 3 N C H H 3 N C H
)
)
)
(CH 2 2 (CH 22 (CH 22
N
COO COO CO H 2
2
2-OG Glu 3 Gln
1 NH H O
2
COO 4 COO
H 3 N C H H 3 N C H
Ala Pyr 4 Ser
C H 3 H 2 C OH
COO
O C
C H 3
1 Alanine transaminase [PLP] 2.6.1.2 3 Glutaminase 3.5.1.2
2 Glutamate dehydrogenase 1.4.1.2 4 Serine dehydratase [PLP] 4.2.1.13

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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