Page 192 - Color Atlas of Biochemistry

Protein Metabolism 183

A. Urea cycle

1 Carbamoyl phosphate synthase (NH ) 3 Argininosuccinate synthase 6.3.4.5
3
6.3.4.16
2 Ornithine carbamoyltransferase 2.1.3.3 4 Argininosuccinate lyase 4.3.2.1
P
N-Acetyl 5 Arginase 3.5.3.1
2 A glutamate 2 A
PP P P P
6 Fumarate hydratase 4.2.1.2
7 Malate dehydrogenase 1.1.1.37
Carbamoyl
phosphate
8 Glutamate dehydrogenase 1.4.1.2
NH 4 1 P NH 2
C 9 Aspartate transaminase [PLP]
COO
O
H N C H COO
3
HCO 3
CH 2 H N C H
3
2
CH 2 Ornithine CH 2 Citrulline
CH 2 CH 2

Transporter H N H P CH 2
H N NH 2 Mitochondrion
Urea H C
O NH 2 O
C COO
H N C H COO
H N 3
2
CH H N C H
5 2 3 A
H O CH 2 CH 2 PP P
2
CH 2 Arginine CH 2 Arginino-
COO CH succinate 3
N NH 2 2
2
C H H C N NH 2 H O
H C P P Cytoplasm
2
H C H N
HN A
COO 4 P
OOC CH C COO
Fumarate 2
H COO
CH
H O COO 2
2
NH 4 H C NH
CH 2 3
6 COO
CH 2
8 COO C O Aspartate
COO
N A
CH 2
CH 2 COO
N A COO CH 2-Oxo-
H C OH N A 2 glutarate
CH 2
COO H C NH 3
C O
Malate 7 COO
COO Glutamate 9
Oxaloacetate

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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