Page 262 - Color Atlas of Biochemistry

Protein biosynthesis 253

A. Elongation and termination of protein biosynthesis in E. coli

Elongation
Peptidyl transferase
3' 1 2.3.2.12 3'
1a 1b
A A
Valine codon GUG Val GUG
CCU EF-Tu P CCU
Pro GTP GDP Pro
P EF-Tu P
Val
Val-tRNA
NH 3 5' NH 3 5'

2

GDP EF-Ts EF-Ts GTP
4

3' 3'
GDP P GTP
A EF-G EF-G A
GUG
Val
Pro
CCUGUG NH 3
Pro Val CCU
P P

3 5'
NH 3
5'
tRNA

If stop codon
in A site tRNA
5 P
GDP 50S
subunit
RF-3
GTP Termination 30S
Termination RF-3 A subunit
factors A Stop
codon
RF-1 GUGUAG 6
Val
Pro P
P
mRNA
Pro Val
NH 3 NH 3 COO
Protein RF-1

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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