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Mammalian Cell Culture 47

to 10,000-L batches of pharmaceuticals. The development Doyle, A., and Griffiths, J. B. (1998). “Cell and Tissue Culture: Labora-
of media containing specific growth factors, together with tory Procedures in Biotechnology,” John Wiley & Sons, New York.
the sophistication of genetic techniques and implantable Doyle, A., and Griffiths, J. B. (2000). “Cell and Tissue Culture for Med-
ical Research,” John Wiley & Sons, New York.
materials, has allowed cell culture to evolve to the use
Freshney, R. I. (1994). “Culture of Animal Cells,” Wiley-Liss, New York.
of the cell itself as a product (or means of producing a Hunkeler, D., Prokop, A., Cherrington, A., Rajotte, R., and Sefton, M.,
substrate) for use in biological processes. eds. (1999). “Bioartificial organs. II. Technology, Medicine and Ma-
terials,” Annals of the New York Academy of Sciences 875.
Jenkins, N., ed. (1999). “Animal Cell Biotechnology,” Humana Press,
Clifton, NJ.
SEE ALSO THE FOLLOWING ARTICLES
Masters, J. R. W. (2000). “Animal Cell Culture—A Practical Approach,”
Oxford University Press, London.
BIOMATERIALS,SYNTHESIS,FABRICATION, AND APPLI- Shepherd, P., and Dean, C. (2000). “Monoclonal Antibodies—A Practi-
CATIONS • BIOREACTORS • CELL DEATH (APOPTOSIS) • cal Approach,” Oxford University Press, London.
DNATESTING INFORENSICSCIENCE•GENEEXPRESSION, Spier, R. E. (1999). “Encyclopedia of Cell Technology,” John Wiley &
Sons, New York.
REGULATION OF • HYBRIDOMAS,GENETIC ENGINEER-
Wurm, F. M. (1997). “Aspects of Gene Transfer and Gene Amplifica-
ING OF • IMMUNOLOGY—AUTOIMMUNITY • METABOLIC tion in Recombinant Mammalian Cells.” In “Genetic Manipulation
ENGINEERING • TISSUE ENGINEERING of Mammalian Cells” (Hj. Hauser and R. Wagner, eds.), pp. 87–120,
Walter de Gruyter, Berlin.
Wurm, F. M. (1999). “Chinese hamster ovary cells, recombinant pro-
tein production.” In “The Encyclopedia of Bioprocess Technology:
BIBLIOGRAPHY
Fermentation, Biocatalysis and Bioseparation” (D. Flickinger, ed.),
pp. 570–581, Wiley, New York.
Campbell, K. H. S., McWhir, J., Ritchie, W. A., and Wilmut, I. (1996). Wurm, F. M., and Bernard, A. (1999). “Large-scale transient expres-
“Sheep cloned by nuclear transfer from a cultured cell line,” Nature sion in mammalian cells for recombinant protein production.” Current
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