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               660                                                                        Lipoprotein/Cholesterol Metabolism


               primary hypoalphalipoproteinemia. The treatment op-  BIBLIOGRAPHY
               tions for these individuals are limited. Thus, the next fron-
               tier in drug development is to develop treatments for low
                                                                 Ballantyne, C. M., Grundy, S. M., Oberman, A., Kreisberg, R. A., Havel,
               HDL or ones that enhance the catabolism of cholesterol.  R. J., Frost, P. H., and Haffner, S. M. (2000). “Hyperlipidemia: Diag-
               The discovery of lipid transport proteins such as ABCA1  nostic and therapeutic perspectives,” J Clin. Endocrinol. Metab. 85,
               provides potential new targets for drug development.  2089–2112.
                                                                 Bors, P., Zelcer, N., and van Helvoort, A. (2000). “ABC transporters in
                                                                   lipid transport,” Biochim. Biophys. Acta. 1486, 128–144.
               XVIII. FINAL PERSPECTIVE                          Brown, M. S., and Goldstein, J. L. (1986). “A receptor-mediated pathway
                                                                   for cholesterol homeostasis,” Science 232, 34–47.
                                                                 Brown, M. S., and Goldstein, J. L. (1999). “A proteolytic pathway that
               Cholesterol has played a distinguished role in the history
                                                                   controls the cholesterol content of membranes, cells, and blood,” Proc.
               of chemistry, medicine, physiology, and pathology. But,  Natl. Acad. Sci. USA 96, 11041–11048.
               unlike any other biomolecule, cholesterol has also taken  Davis, R. A. (1999). “Cell and molecular biology of the assembly and
               center stage as a cultural entity. In most nations, regardless  secretion of apolipoprotein B-containing lipoproteins by the liver,”
                                                                   Biochim. Biophys. Acta 1440, 1–31.
               of scientific training, people think about cholesterol when
                                                                 Ginsberg, H. N. (2000). “Insulin resistance and cardiovascular disease,”
               they shop for food, plan their diets, and make lifestyle  J. Clin. Invest. 106, 453–458.
               choices. There is a large food supplement industry that  Krieger, M. (1999). “Charting the fate of the ‘good cholesterol’: Identi-
               promotes products based on claims to lower cholesterol.  fication and characterization of the high-density lipoprotein receptor
                 One positive outcome of the cultural presence of choles-  SR-BI,” Annu. Rev. Biochem. 68, 523–558.
                                                                 Mahley, R. W., and Huang, Y. (1999). “Apolipoprotein E: From
               terol has been a high level of public education in the area
                                                                   atherosclerosis to Alzheimer’s disease and beyond,” Curr. Opin. Lipi-
               of lipid metabolism—millions of people know the differ-  dol. 10, 207–217.
               ence between LDL and HDL. This level of public sophis-  Rothblat, G. H., de la Llera-Moya, M., Atger, V., Kellner-Weibel, G.,
               tication in details of biochemistry is unprecedented and  Williams, D. L., and Phillips, M. C. (1999). “Cell cholesterol ef-
               demonstrates that scientific literacy in other fields is also  flux: Integration of old and new observations provides new insights,”
               possible and achievable. During the past 30 years, people  J. Lipid Res. 40, 781–796.
                                                                 Russell, D. W. (1999). “Nuclear orphan receptors control cholesterol
               in many Western nations have adopted healthier diets and
                                                                   catabolism,” Cell 97, 539–542.
               lifestyles, leading to a dramatic drop in the rate of coronary  Tall, A. R., Jiang, X.- C., Luo, Y., and Silver, D. (1999). “George Ly-
               heart disease.                                      man Duff memorial lecture: Lipid transfer proteins, HDL metabo-
                                                                   lism, and atherogenesis,” Arterioscler. Thromb. Vasc. Biol. 20, 1185–
                                                                   1188.
               SEE ALSO THE FOLLOWING ARTICLES                   Terpstra, V., van Amersfoort, E. S., van Velzen, A. G., Kuiper, J., and van
                                                                   Berkel, T. J. (2000). “Hepatic and extrahepatic scavenger receptors:
                                                                   Function in relation to disease,” Arterioscler. Thromb. Vasc. Biol. 20,
               BIOENERGETICS • ENZYME MECHANISMS • GENE EX-
                                                                   1860–1872.
               PRESSION,REGULATION OF • ION TRANSPORT ACROSS     Willnow, T. E., Nykjaer, A., and Herz, J. (1999). “Lipoprotein receptors:
               BIOLOGICAL MEMBRANES • PROTEIN SYNTHESIS            New roles for ancient proteins,” Nat. Cell Biol. 1, E157–E162.
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