Page 427 - Environmental Nanotechnology Applications and Impacts of Nanomaterials

References Shvedova et al., 2003 Cunningham et al., 2005; Zhang et al., 2007 Cui et al., 2005 Kam et al., 2004 Sayes et al., 2006 Kagan et al., 2006 Manna et al., 2005 Monteiro-Riviere et al., 2005a Monteiro-Riviere 2005; Witzmann and Monteiro- Riviere, 2006

Negative Impacts of Carbon-Based Nanomaterials on Living Mammalian Cells and Organisms (Continued)

Effects observed Genes induction (structural proteins Decrease in cell proliferation and cell Endocytosis, intracytoplasmic localization, Increase in the side-wall functionalization Loss of intracellular thiols and accumulation of lipid peroxides Activation of oxidative stress and nuclear Int

Cellular toxicity and cytokines) adhesion extensive cell death decrease cytotoxicity transcription factor-kB

Organisms, or cell types, or organelles Human epidermal (HaCaT) cells Human epidermal keratinocytes Human embryo kidney HEK293 cells Human promyelocytic leukemia (HL60) cells and human T (Jurkat) cells Fibroblasts Macrophages Immortalized keratinocytes Human epidermal keratinocytes

TABLE 11.1 Type of nanomaterials SWCNT– biotin-streptavidin complex Functionalized carbon nanotubes Iron-rich SWCNT MWCNT

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