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Cable-driven flexible endoscope utilizing diamond-shaped perforations: FlexDiamond 45
                         Table 3.2: Anatomical measurements and FlexDiamond design dimension.

                Parameters            Anatomical restrictions   Design specifications (FlexDiamond)
                Diameter (outer)         Less than 8.8 mm        7mm
                                        (Caucasians)             Due to the resolution limit from rapid
                                         Ideally between 4 6mm   prototyping
                                        (based on dimensions of
                                        diagnostic endoscopest)
                Diameter (inner)                                4 mm for housing the camera
                Insertion length      Minimum 100 mm            Mechanical zooming segment: bend radius
                                                                of 16 mm, with 25 mm flexes length; total
                                                                length 5 300 mm
                Length of workspace in the  B18.5 mm (sagittal diameter  Mechanical zooming segment: 25 mm
                nasopharynx region     of the nasopharynx)       Bending segment: 25 mm
                (sagittal plane)
                Length of workspace in the  B24.50 mm (transverse  Mechanical zooming segment: bend
                nasopharynx region     diameter of nasopharynx)  radius of 16 mm, with 25 mm flexes
                (transverse plane)                               length (mechanical zoom up to 5 mm)
                Bending angle                                   90 degrees or more
                Control system                                  30 cm by 20 cm by 30 cm


               3.2.2.1 Anatomical variations and robot shape morphing

               A soft robotic manipulator can minimize the discomfort induced in the subjects during
               endoscopy. Due to the use of soft materials for fabrication of the prototype, it also enables
               the prototype to conform to the shape variations of nasal passages that might be slightly
               constricted or have irregular shapes. The flexibility of the bending segment allows the
               prototype to screen the nasopharynx by bending at different angles. The third DOF also
               allows the prototype to reach into regions that may be deeper and narrower in the
               nasopharynx via the longitudinal extension of the camera, thus allowing optical zooming.

               3.2.2.2 Anatomical variations in terms of size
               Anatomical variations of the nasal passage, cavity, and the nasopharynx volume between
               different individuals impose a design criterion that caters to the needs of different subjects.
               The anthropometric measurements from the nasal inlet to the nasopharynx should be
               considered during prototype development to maximize patient comfort.
               3.2.2.3 Anatomical variations based on age and gender

               We are interested in the nasopharyngeal volume (V 1 ), the airway cross-sectional area of the
               nasopharynx (CSA1), a sagittal diameter of nasopharynx (SD1), and transverse diameter of
               nasopharynx (TD1) [12]. For adolescences, V 1 , CAS1, SD1, TD1 TD4, and
               glossopharyngeal length show no statistically significant differences between genders.
               Nonetheless, it was found that CSA1, SD1, and V 1 increase for elder subjects [12,13].
               Hence since the target audience only includes adults, and the nasopharynx dimensions
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