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              for other applications, and the patent protection was solid. They
              addressed concerns by focusing on those aspects of the project
              that were well known, rather than focusing on what was new.
                 Moreover, the Cellular Therapies team spent time up front
              rigorously understanding the cardiology market and design-
              ing cogent business models. It validated the market opportu-
              nity, explored payers and pricing and potential adoption rates
              of comparable products, and assessed internal costs and
              requirements for Baxter to manufacture, sell, and support the
              product. As Uppal explained, “At Baxter, to garner funding,
              you need to have a complete hypothesized business model up
              front. . . . It’s of course chock full of assumptions . . . but you
              continue to refine it over time.”
                 With a clear business model and initially successful clinical
              trials in hand, Cellular Therapies began the internal sales process
              to win support for the program, which proved to be more of a
              challenge than the team had anticipated. While the company’s
              heritage selling refills for dialysis equipment suggested the
              power of the razor-and-razor-blade business model, the NTRI
              team encountered skepticism regarding the model’s viability.
              Each patient administration of the technology would require a
              new cartridge costing upwards of $5,000—the “razor blade” of
              the system. The analogous dialysis refill products retailed for
              around $20. While the model was the same, it had a higher price
              point than other Baxter disposables. This price difference caused
              many people to discount the viability of the model, even though
              it was the same razor-and-razor-blade model.
                 Baxter was still building its capabilities and penetration
              within the health-care bio products markets, where high per-
              use price points were more common than in Baxter’s traditional
              markets. As a result, convincing people of the feasibility of the
              business model and the likelihood of market acceptance proved
              nearly as difficult as selling the company on the science. The
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