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Leadership from All Le vels     207


              team hired a statistician to evaluate similar drugs, surveyed
              doctors, analyzed likely reimbursement rates, and compared
              these to internal costs. The results were compelling and made
              the case with hard data.
                 Nonetheless, the system had failed to build significant rev-
              enues for oncological applications, which meant that Baxter
              subjected the cardiac application to much higher hurdles of
              proof for the opportunity’s revenue potential. The original
              Nexell product had failed to achieve anywhere near revenue
              expectations for cancer-related indications, so some managers
              within Baxter were concerned about repeating the same mis-
              take. How could this underperforming business ultimately
              make a meaningful contribution to Baxter’s growth simply by
              transferring the technology to another application?
                 The Cellular Therapies project team persevered, created a
              solid plan for engaging the cardiac community, and built a
              solid business case, while Riedel and Hunt continued to shep-
              herd the program. However, while the CSO’s office could keep
              a Phase I FDA trial protected within its confines, Phase II tri-
              als posed a greater challenge. A Phase II trial required upwards
              of $25 million to conduct, representing more than 5 percent of
              the company’s entire R&D for 2007.
                 It became imperative for Riedel and Hunt to muster support
              from Baxter’s core business leaders. As Hunt recalled, “It was
              a constant, uphill sales effort to build the support we needed,
              but we didn’t have a choice. . . . You’ve got to reach out to peo-
              ple early and often, and just continue doing so. It’s not easy to
              take a company in a new direction, even if it looks like just the
              right thing to do.”
                 Given that Cellular Therapies did not fall within the purview
              of any business unit, making the case for Phase II funding pre-
              sented a significant challenge. Because it meant taking Baxter
              in new directions, the Cellular Therapies team faced much
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