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CHAPTER TWELVE



              Bioinspired and Biomimetic

              Micro-Robotics for Therapeutic

              Applications


              Ahmet Fatih Tabak
              Max-Planck Institute for Intelligent Systems, Stuttgart, Germany

              Contents
              1 Motivation                                                  457
              2 Background                                                  460
               2.1 Observations of Bacteria and Spermatozoa                 462
               2.2 Physics of Swimming in Micro-Realm                       463
               2.3 Experiments                                              475
              3 Building a Micro-Swimmer Robot                              482
               3.1 Manufacturing Techniques                                 484
               3.2 Biocompatibility and Functionalization                   488
               3.3 Actuation and Energy Supply                              493
              4 Modeling a Micro-Swimmer Robot as an End-Effector           499
               4.1 Evolution of Equation of Motion                          499
               4.2 Equation of Motion                                       500
               4.3 Stability and Controllability in the Wake of Efficiency  509
              5 Epilog: Future Directions                                   513
              References                                                    517






                   1 MOTIVATION
                   The notion of tiny robots performing inside biological systems is one of
              the most science-fiction ideas subtly explored in the pop culture with different
              versions envisioned in movies such as Fantastic Voyage (20th Century Fox,
              1966), Innerspace (Amblin Entertainment & Warner Bros., 1987), and The
              Island (Parkes/MacDonald Productions & DreamWorks & Warner Bros.,
              2005), and in TV series such as Star Trek Voyager (Paramount Network
              Television & CBS Television Distribution, 1995–2001). If one looks for
              the pattern of evolution of such systems portrayed in the silver screen, it will
              be clear that the perception changed from manned generic vehicles shrunk in

              Handbook of Biomechatronics                 © 2019 Elsevier Inc.  457
              https://doi.org/10.1016/B978-0-12-812539-7.00010-6  All rights reserved.
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