Page 459 - Handbook of Biomechatronics

The Artificial Pancreas 453

Fig. 31 Modular architecture for a closed-loop artificial pancreas. (Based on Patek, S.,
Magni, L., Hughes-Karvetski, C., Toffanin, C., DeNicolao, G., DelFavero, S., Breton, M.,
DallaMan, C., Renard, E., Zisser, H., DoyleIII, F., Cobelli, C., Kovatchev, B., 2012. Modular
closed-loop control of diabetes. IEEE Trans. Biomed. Eng. 59(11): 2986–2999.)

algorithms to be easily implemented without requiring changes to the core
CGM or pump hardware.
Future automation of insulin delivery will be further supported by the
introduction of algorithms that are capable of using multiple signals to better
determine the physiological state of the person. Studies of multihormonal
systems will gauge the viability of insulin plus glucagon control and of alter-
natives like insulin plus pramlintide. Finally, all of these systems will benefit