Page 390 - Handbook of Properties of Textile and Technical Fibres

Structure and behavior of collagen fibers 363

understanding of collagen biomechanics is necessary since the time-dependence and
deformation mechanism must be considered in order to provide accurate interpreta-
tions of the mechanical properties. This also requires the use of “gold standards” to
make sure any new test developed can duplicate the behaviors that have been reported
in the literature in the pioneering research of Yamada (1970) and Fung (1973).
Future studies are needed to identify the changes that occur in collagen fibers and
their mechanical properties found in tissues that are associated with cancers and other
pathologies (Dudea et al., 2013). Collagen fibers in ECMs are oriented in more than
one direction and form multilayered sheets such as is observed in skin, cartilage,
and bone. Changes in packing patterns and fiber orientation may be a useful criterion
for early diagnosis of a number of disease states.

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