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i 74                           CHAPTER 5 PHYSIOLOGICAL AND TOXICOLOGICAL CONSIDERATIONS

                     5.2.6 Endogenous Ammonia Production  220
                     5.2.7 Respiratory Defense Mechanisms  221
                         References  229
                         Bibliography  234
                         Glossary  234
                  5.3 TOXICITY AND RISKS INDUCED BY OCCUPATIONAL EXPOSURE
                     TO CHEMICAL COMPOUNDS         239
                     KAI M. SAVOIAINEN AND
                     PENTTI KALLIOKOSKt
                     53.1 Introduction and Background  239
                     53.2 Exposure to Chemical Substances  2SS
                     S.33 Kinetics of Chemical Compounds  263
                     5.3.4 Toxic Effects of Chemical Compounds  276
                     5.3.5 Exposure Assessment  320
                     5.3.6 Toxicity, Risks, and Risk Assessment  326
                         References  336
                         Bibliography  344
                  5.4 VENTILATION NOISE—CHARACTERISTICS, EFFECTS, AND SUGGESTED
                     COUNTER-MEASURES       345
                     ULF tANDSTROM
                     5.4.1 Occurrence  345
                     5.4.2 Ventilation Noise as an Environmental Problem  345
                     5.4.3 Physical Characteristics  346
                     5.4.4 Noise Generation  347
                     5.4.5 Effects on Humans  347
                     5.4.6 Measures  351
                     5.4.7 Exposure limits  353
                         References  353






        5.1 THERMAL COMFORT


        5.1.1 Introduction
                 Humans seek and want thermal comfort, even at work in industrial settings.
                 Clothing, activities, posture, location, and shelter are chosen, adjusted, al-
                 tered, and sought consciously and unconsciously to reduce discomforts and
                 enable us to focus more on the other tasks of life. Discomfort can contribute
                                                                      1 4
                 to mistakes, productivity decreases, and industrial accidents. "  Thermal dis-
                 comfort results from the physiological strain of thermoregulation. The strain
                 can be in the form of altered body temperatures, sweating and excessive skin
                 moisture, muscle tension and stiffness, shivering, and loss of dexterity. A small
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