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I 76                           CHAPTER 5 PHYSIOLOGICAL AND TOXICOLOGICAL CONSIDERATIONS

                 illustrates that as conditions deviate from neutral the body activates mechanisms
                 to stabilize body temperature. These efforts all result in small but noticeable and
                 measurable increases in metabolism and physiological effort.

                     Body Temperature
                     To maintain proper body temperatures (T), metabolic energy (M) must be
                 continuously transferred to the environment.
                                            Energy balance:





                 where






                 The body temperature limits for health in terms of internal or core tempera-
                 ture are fairly limited. The limits are basically related to the function of ner-
                 vous tissue. Body temperatures around 28 °C or less can result in cardiac
                 fibrillation and arrest. Temperatures of 43 °C and greater can result in heat
                 stroke, brain damage, and death. Often, too high a temperature causes irre-
                 versible shape changes to the protein molecules of nervous tissue. That is,
                 cooling overheated tissue to normal temperatures may not restore its original
                 function.
                     Metabolism
                     Metabolism is often characterized by a convenient, relative, and dimen-
                 sionless quantity called the met unit:



                     The metabolism of a resting person is then 1 met. Some met levels of vari-
                 ous activities are listed in Table 5.2.
                     Metabolic energy is often normalized in terms of energy per unit area of
                                      2
                 skin (1 met = 58.2 W/m ):




           BH TABLE 5.2 Met Level of Various Activities

                 Reclining                -0.8 met  Walking 5 km/h       ~3 met
                 Seated and quiet         -1.0 met  Standing and heavy activity  ~3 met
                                                    (heavy work, garage work)
                 Standing                 -1.2 met  Basketball           -5-8 met
                 Standing and light activity  -1.6 met  Max              -10-12 met
                   (shopping, lab, light industry)
                 Standing and medium activity  -2 met
                   (house work, machine work)
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