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238                            CHAPTER 5 PHYSIOLOGICAL AND TOXICOLOGiCAL CONSIDERATIONS

                  Norihygroscopic: Material that resists adsorbing or absorbing atmospheric
                     water vapor.
                  Noxious: Injurious.
                  Olfaction:  The physiological function of sensing odors.
                  Oral cavity:  Airway passage between the lips and lower border of the soft
                     palate.
                  Oronasal breathing:  Breathing simultaneously through both the nasal and
                     oral cavities.
                  Qropharynx: Airway passage between the lower border of the soft palate
                     and epiglottis.
                  Oxygen uptake:  Rate of oxygen transfer from air resident in the pulmonary
                     airways to the pulmonary bloodstream. This is driven by the oxygen con-
                     centration gradient and depends on metabolic demand.
                  Parenchyma: The essential or specialized part of an organ; gas exchange
                     portions of the respiratory tract (alveoli, respiratory bronchioles).
                  Particle growth:  Increase in particle size due to hydration.
                  Partition coefficient:  Quantitative expression of the partition equilibrium of
                     a material between two immiscible liquid phases; usually expressed as the
                     ratio of concentrations between the two phases.
                  Patency:  Extent of a conduit (airway, blood vessel) being open or not obstructed.
                  Pathogen: Disease-producing organism or substance.
                  Peak expired flow (PEP):  Gas volume forcibly expired within the time inter-
                     val t (typically t = 1.0 seconds).
                  Perfusion:  Passage of blood through a blood vessel.
                  Peribronchial surface:  Surface surrounding a bronchus.
                  Periciliary fluid: Transepithelial secretion along the conducting airways con-
                     sisting primarily of water.
                  Phagocytosis:  Process describing the engulfment and destruction of extra-
                     cellularly-derived materials by phagocytic cells, such as macrophages and
                     neutrophils.
                  Pleura:  Folded membrane surrounding the lungs. Space between the visceral
                     and parietal layers (pleural space) is fluid-filled and determines transpul-
                     monary pressure.
                  Poiseuille flow: Parabolic laminar flow in a straight tube.
                  Portal: The point at which something enters the body; in the airway, the
                     nares or lips.
                  Proximal: In the airways, positioned relatively closer to the nares.
                  Pulmonary:  Pertaining to or affecting the lungs.
                  Pulmonary airways:  Portion of respiratory tract (alveoli, respiratory bron-
                     chioles) where gas exchange occurs.
                  Pulmonary perfusion rate: Volumetric flow rate within the pulmonary veins.
                  Reentrainment: Return of material to an airstream after deposition onto a
                     surface.
                  Residence time: Time interval during which an identifiable portion of a
                     fluid flow remains within a given volume.
                 Residual volume (RV): Minimum non-collapsible volume within the airway.
                  Resistance vessels:  Microcirculatory blood vessels (arterioles, pre-capillary
                     sphincters) used to regulate blood flow in a specific tissue.
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