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Chapter 1





             Variable Order Fractional


             Derivatives and Bone
             Remodeling in the Presence of


             Metastases



                                    ´
             Joana P. Neto, Duarte Valerio and Susana Vinga
             Universidade de Lisboa, Lisbon, Portugal


             1.1  INTRODUCTION
             This chapter deals with variable order fractional derivatives, which are a gen-
             eralization of fractional order derivatives.


             1.1.1  What Are Variable Order Fractional Derivatives?
             Fractional order derivatives are, of course, themselves a generalization of usual
             integer order derivatives and integrals, known from Calculus. Differentiation
             and integration notions of orders nAN are, in Fractional Calculus, generalized
             to account for orders αAR (Wheeler, 1997). But since all real numbers are now
             available as orders, it is now rather easy to conceive variable order derivatives,
             with an order that changes with time. Among the first papers on the subject
             were Samko (1995) and Lorenzo and Hartley (2002a), mostly based upon the
             Riemann Liouville definition of fractional derivatives. Variable order deriva-
             tives have been further developed in Vale ´rio and Sa ´ da Costa (2011b); Vale ´rio
             and Sa ´ da Costa (2013), using not only the Riemann Liouville definition,
             but also the Gru ¨nwald Letnikoff and the Caputo definitions. Additional
             insights are provided in Sierociuk et al. (2015a,b) and Sierociuk and
             Malesza (2017), including experiments with electronic circuits imple-
             menting the relevant mathematical operators.
                These variable order derivatives are useful in practice, just as fractional
             derivatives of constant order are. In fact, being more than 300 years old,





             Mathematical Techniques of Fractional Order Systems. DOI: https://doi.org/10.1016/B978-0-12-813592-1.00001-5
             © 2018 Elsevier Inc. All rights reserved.                     1
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