Page 16 - Modern Derivatization Methods for Separation Sciences
P. 16
Document Página 2 de 3
6. Derivatization for Resolution of Chiral Compounds 217
Toshimasa Toyo'oka
6.1. Introduction 218
6.1.1. Fundamentals of Stereochemistry 218
6.1.2. Chirality and Biological Activity 220
6.1.3. Chirality Application as Single Isomers 222
6.2. Resolution of Racemates 223
6.2.1. Direct Resolution 223
6.2.2. Indirect Resolution 223
6.3. Reactions of Various Functional Groups 225
6.3.1. Amines 225
6.3.2. Carboxyls 226
6.3.3. Hydroxyls 227
6.3.4. Thiols and Others 227
6.4. Derivatization for LC Analysis 228
6.4.1. Label for Alcohols 228
6.4.2. Label for Carboxylic Acids 230
6.4.3. Label for Aldehydes and Ketones 231
6.4.4. Label for Other Functional Groups 233
6.5. Derivatization for LC Analysis 233
6.5.1. Label for UV-VIS Detection 235
6.5.1.1. Label for Primary and Secondary Amines 235
6.5.1.2. Label for Carboxylic Acids 240
http://emedia.netlibrary.com/nlreader/nlreader.dll?bookid=17968&filename=Page_ix.html 30/09/2003
