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of fluorophores derived from the fluorogenic reaction and fluorescence labelling reaction. This is one of
the most sensitive detection methods, capable of detecting fmol-amol levels. However, this detection
system is not applicable to all fluorescent materials, a notable disadvantage. In Chapter 5, the theory of
electrochemical reactions and derivatization for eictrochemical detection are described, together with
some examples. Detection is based on a redox reaction of the electrodes and is suitable for compounds
easily oxidized and reduced with low potential. Finally, chiral resolution continues with the
derivatization for effective separation and high-sensitivity detection.

There are some excellent books on derivatization, but they do not address the specifics of the topic.
Each chapter includes sufficient references to the literature to serve as a valuable starting point for more
detailed investigations.

As shown in the bibliography, scientists in Japan are very active in these fields. The contributors and
the authors selected for this book are outstanding research chemists. This book should be useful to
many investigators in various fields, including clinical, pharmaceutical, biological and environmental.

The editor would like to express sincere thanks to the authors for their contributions, as well as to their
colleagues for providing stimulating discussions. Thanks are also due to the entire publishing staff at
John Wiley &

Sons for their continued support and contribution towards the completion of this book.

TOSHIMASA TOYO'OKA
SHIZUOKA, JAPAN

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