Page 25 - Modern Derivatization Methods for Separation Sciences

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1—
Pre-treatment for Real Sample Analysis and Choice of Suitable Reagent

1.1—
Derivatization for Drugs

Akihiko Nakagawa, and Yukinori Kawahara
Analytical and Metabolic Research Laboratories, Sankyo Co.Ltd., Tokyo, Japan

1.1.1. Introduction 2

1.1.2. Application of Derivatization of Drugs 2

1.1.2.1. Determination of Pravastatin Sodium in Plasma by HPLC 2
with Laser-induced Fluorescence Detection after Immobilized
Antibody Extraction

1.1.2.2. Enantiospecific Determination of Ibuprofen in Rat 4
Plasma Using Chiral Fluorescence Derivatization Reagent, (-)-2-
[4-(1-aminoethyl)phenyl]-6-methoxybenzoxazole

1.1.2.3. Specific Fluorogenic Derivatization of Ivermectin Using 6
Non-fluorescent Reagents

1.1.2.4. Other Methods 8

1.1.3 Conclusion 10

References 11

Edited by Toshimasa Toyo'oka: Modern Derivatization Methods for Separation Sciences (c) 1999 John Wiley &
Sons Ltd.

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