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Fig. 1.1.3.
Influence of diethyl phosphorocynidate (DEPC) and triethylamine
(TEA) concentrations on the derivatization. [Reproduced from ref.
3, p. 1633, Fig. 3.].

Fig. 1.1.4.
Comparison of the detection limit of N-dansyl-
ethylenediamine derivative of pravastatin sodium
by three different detectors in HPLC. A;
UV (239 nm) detection with 10 ng/injection,
B; conventional fluorescence detection
(Ex. 350 nm and Em. 530 nm) with 50 pg/injection
and C; laser-induced fluorescence detection
with 15 pg/injection. [Reproduced from ref.
3, p. 1634, Fig. 5.].

alone and with the two columns by the columnswitching technique is shown in Fig. 1.1.5. The limit of
quantitation of the method was 100 pg/ml when 1 ml of plasma sample was available. An average
coefficient of variations of the overall method were less than 8% at the concentration range of 1-100
ng/ml.

1.1.2.2—
Enantiospecific Determination of Ibuprofen in Rat Plasma Using Chiral Fluorescence
Derivatization Reagent, (-)-2-[4(1-aminoethyl)phenyl]-6-methoxybenzoxazole

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