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15. Diffusion Processes
                              326
                              for X 0 = x 0 . The limiting value of η/(1−f) is the same as the deterministic
                              equilibrium. In the case of neutral evolution with f = 1 and η = 0, the
                              mean E(X t )= x 0 is constant. In these circumstances, equation (15.15)
                              reduces to
                                                                          2
                                               d              E(X t ) − E(X )
                                                                          t
                                                 Var(X t )=
                                               dt                  2N
                                                                    2
                                                              x 0 − x − Var(X t )
                                                                    0
                                                          =                   ,
                                                                     2N
                              with solution

                                                                            t
                                              Var(X t )= x 0 (1 − x 0 ) 1 − e − 2N .
                              This expression tends to x 0 (1 − x 0 )as t tends to ∞, which is the variance
                              of the limiting random variable
                                                      ,
                                                   =    1 with probability x 0
                                                        0 with probability 1 − x 0 .
                                             X ∞
                              Fan and Lange [5] calculate Var(X t ) for the dominant case. In the recessive
                              case, this approach to E(X t ) and Var(X t ) breaks down because µ(t, x)is
                              quadratic rather than linear in x.
                              15.6 Equilibrium Distribution


                              In certain situations, a time-homogeneous diffusion process will tend to
                              equilibrium. To find the equilibrium distribution, we set the left-hand side
                              of Kolmogorov’s equation (15.5) equal to 0 and solve for the equilibrium
                              distribution f(x) = lim t→∞ f(t, x). Integrating the equation

                                                    d              1 d 2    2
                                            0= −       µ(x)f(x) +     2  σ (x)f(x)       (15.16)
                                                    dx             2 dx
                              once gives

                                                                 1 d     2
                                                  = −µ(x)f(x)+        σ (x)f(x)
                                              k 1
                                                                 2 dx
                              for some constant k 1 . The choice k 1 = 0 corresponds to the intuitively
                              reasonable condition of no probability flux at equilibrium. Dividing the no
                                               2
                              flux equation by σ (x)f(x) yields
                                                   d    2             2µ(x)
                                                     ln[σ (x)f(x)]  =      .
                                                                       2
                                                  dx                  σ (x)
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