Page 376 - Applied Probability
P. 376
Index
366
speed of, 18
Risk, 102, 110
Risk prediction, 128
for myotonic dystrophy, 128,
Sequence alignment
134
listing, 285
for recessive disease, 134
multiple, 292–293
for X-linked recessive, 135 Selfing, 93, 195
pairwise, 283–292
under polygenic threshold model, local similarity, 291–292
157 maximum similarity, 290–
Risk ratio, 102 291
two-locus models, 103–105, 112 minimum distance, 285–288
RNA number of, 284–285, 295
16s ribosomal, 216 significance of, 308–311
messenger, 341, 343
Sequence tagged sites, 248
polymerase, 344
Sex chromosome, see Chromosome(s),
premessenger, 343
sex
strand, 341 Sherman-Morrison formula, 46
structure, 341
in posterior mode calculation,
transfer, 344
247
Robust linkage analysis, see Link-
Sickle cell anemia
age analysis
and heterozygote advantage,
Root of evolutionary tree, 203
11
Silencer region, 342
Scan statistic, 306
Simulated annealing, 174
Schizophrenia, risk ratios for, 105
for haplotyping, 186–187
Schr¨odinger’s randomization tech-
for ordering loci, 233
nique, 259
Single nucleotide polymorphism,
Score, 39
127
for Dirichlet distribution, 55
Sister chromosomes, see Chromo-
for Dirichlet-multinomial dis-
somes, sister
tribution, 49
Smith-Waterman algorithm, 291–
for multivariate normal, 144
292
for some exponential families,
42 Software, xi
Scoring method, 39 Somatic cell hybrid, 301, 347
for inbreeding coefficient and model for panel construction,
allele frequency, 42 313
for mean and variance com- panel of chromosome indica-
ponents, 142 tors, 302
relation to least squares, 53 assumptions, 303
Secant condition, 46 error detection and correc-
Segmental function, 275 tion, 303, 313
Segregation parameter, 126 Southern blotting, 345
Segregation ratio, 5, 27 Spacing of markers, 306
Selection, 9 Sperm, 1
balance with mutation, 12, 17 State space, 170
