Page 371 - Applied Probability

361
Index
computation of, 88–91
relation to disease risk, 109
used in robust linkage analy-
under sib mating, 93
sis, 106
Indel, 284
Independence testing, see Link-
age equilibrium, testing
in QTL mapping, 195
relation to identity coefficients,
for in calculating risk ratios, 102
Infinitesimal transition matrix, 210 85
eigenvalues of, 224, 225 X-linked, 93
probability, see Transition rate generalized, 94
Information in QTL mapping, 164
expected, 40–42 Kinship matrix, 83
as efficiency of experimen- diagonalization, 92, 111
tal design, 43–45 QTL mapping, 150
EM algorithm, 55 Kolmogorov’s circulation criterion
for Dirichlet distribution, continuous time, 210
55 discrete time, 171
for multivariate normal, 145, Kolmogorov-Smirnov test, 283
159 Kosambi’s map function, see Map
for power-series family, 53 function, Kosambi’s
for radiation hybrids, 251, Kronecker product, 148, 161
253
multinomial, 54 Lagrange multiplier, 27
observed, 39 Lander-Green-Kruglyak algorithm,
for Dirichlet-multinomial dis- 122, 188–191
tribution, 49 in haplotyping, 198
for multivariate normal, 144 Laplace’s method used in approx-
Intensity measure, 257 imating integrals, 248
Interarrival distribution, 262 Levenshtein metric, 283, 286
for Poisson-skip model, 277 Liability, 154
Interphase, 347 Likelihood ratio statistic
Intron, 344 for QTL mapping, 151
Irreducibility (ergodic assumption), for testing allele frequency dif-
170 ferences, 61
Ising model, 220, 227 for testing Hardy-Weinberg equi-
Iterated sum, 120–122, 243 librium, 60, 62, 73
greedy algorithm for, 121, 133 for testing segregation para-
meters, 126
Jensen’s inequality, 24 Linear algebra, some review of,
142–144
Kimura’s model, see Evolution, neu- Linkage analysis, 4, 346
tral QTL mapping, 151
Kinship coefficient, 81 robust methods for, 106–109
algorithm for computing, 82– using lod and location scores,
83 129–133
generalized, 86–91 Linkage equilibrium, 4