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CHAPTER
5
Cell therapy
Chapter outline
5.1 Adoptive cell-based therapy in combination with chemotherapy .......................... 115
5.1.1 Cancer therapy with TIL ..................................................................116
5.1.2 Cancer therapy with TCR ................................................................117
5.1.3 CAR T cell therapy ........................................................................117
5.1.4 Dendritic cell-based therapy ...........................................................119
5.2 Innate cell-based therapy .................................................................................. 120
5.2.1 Innate cells ...................................................................................120
5.2.2 Innate lymphoid cells .....................................................................121
5.2.3 NK cells ........................................................................................121
5.2.4 Innate or adaptive immunity? ..........................................................123
5.2.5 Preclinical and clinical examination of innate cell therapy .................123
5.3 Progenitor stem cell therapy .............................................................................. 124
5.3.1 Hematopoietic progenitor cells in cancer therapy ..............................125
5.3.2 IPSC in cancer therapy ...................................................................126
References .............................................................................................................. 127
5.1 Adoptive cell-based therapy in combination with
chemotherapy
The effect of the immune system is to eliminate cancer cells before clinical expres-
sion. It provides the immunological reaction to the specific antigens of tumor cells
that can eradicate them [1]. It happens when there is a balance between cancer and
the immune system. Once this balance disturbed, tumor cells can develop and have
clinical expression. Immunotherapy techniques are to boost the immune response
against tumor cells, and they have shown themselves as the first broadly techniques
to treat metastatic cancer [1,2]. Immunotherapy techniques have been tried to treat
the cancers and improve other techniques with little or no toxicity to normal tissue. It
has offered more safety to traditional chemotherapy with more long-term protection
through immunological memory [1].
With knowledge of the relationship between immune cells, cancer cells, different
tumor escape mechanisms and their functions have grown rapidly; a new technique
Bio-Engineering Approaches to Cancer Diagnosis and Treatment. http://dx.doi.org/10.1016/B978-0-12-817809-6.00005-4 115
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