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6.4 NIR-triggered anticancer drug delivery 147
FIGURE 6.5 Live/death assay of LBL Lipo-graph fluorescent microscopy (the scale bar is
200 µm) [65].
Having high cross-section absorption and feasibility to drug binding, gold-based
nanoparticles absorbed a great deal of attention in PT-NIRSRS. For example, gold
nanoparticles and doxorubicin were embedded in pores of mesoporous silica. Then
the chemo-photothermal therapy potentials of the carriers were examined on A549
cells. Their results demonstrated enhancing drug release in the presence of GSH
and light irradiation [67]. In another study, the chemo-photothermal effect of GNR
embedded in hydrogel was examined by Qu et al. Their thermoresponsive hydrogel
was composed of N-isopropylacrylamide loaded with doxorubicin and GNRs. Their
