Page 245 - Cascade_Biocatalysis_Integrating_Stereoselective_and_Environmentally_Friendly_Reactions

9.2 Enzyme-Catalyzed Stereoselective Reactions in Continuous-Flow Systems 221

r (0 °C)
E r (30 °C)
or × E (0 °C)
−1
−1
r (μmol min g )
E (30 °C)
25
× × × 15
× × × ×
20 12
r flow (μmol min −1 g −1 ) 9
15 6
3 × × ×
10 × × × × ×
0
0 10 20 30 40 50 60 70
Temperature (°C)
5
0
1 20 40 60 80 100 120
Pressure (bar) CaLB N435
× CaLB T2-150
CaLB G250P
r (1 bar) CaLB SG10A
r (120 bar)
E E (1 bar)
or ×
−1
−1
r (μmol min g ) E (120 bar)
30
1500
×
25 × 1200
× 900 ×
20 × ×
E (−) 600 ×
×
15 300
× × ×
× × 0 ×
10 0 10 20 30 40 50 60 70
× Temperature (°C)
5
0
0 10 20 30 40 50 60
Temperature (°C)
O
O HN
O

(a) (b)
(R)-24h (R)-20d