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274   Biofuels for a More Sustainable Future


          scenario where at least a 50% chance of limiting the average global temper-
          ature increase to 2°C by 2100) (IEA, 2017).
             To accelerate the adoption of biofuel, it is critical to produce and deliver
          biofuel in a cost-effective, robust, and sustainable way (Yue et al., 2014;
          Daoutidis et al., 2013; Marquardt et al., 2010). The economic feasibility,
          environmental impacts, and social implications of biofuel highly depend
          on the design and operation of the entire biofuel supply chain (BSC)
          (Awudu and Zhang, 2012; Sims et al., 2010; Iakovou et al., 2010). BSC usu-
          ally involves a broad range of activities ranging from biomass production and
          transportation to biorefinery, and distribution to final end-use customers.
          Therefore it is challenging to design the entire BSC from a system perspective.
          Compared to traditional supply chains in the manufacturing industries, BSC is
          more complex given the large uncertainties and variabilities related to feed-
          stocks (Awudu and Zhang, 2012; Santoso et al., 2005; Kim et al., 2011), con-
          version technologies (Iakovou et al., 2010; Kim et al., 2011; Rentizelas et al.,
          2009a; McKendry, 2002), and transportation network (An et al., 2011a).
             Intensive efforts have been made in the past decades by researchers and
          the industry to develop optimization and simulation models for BSC to solve
          practical design problems in producing and delivering biofuel. This chapter
          reviews the literature related to BSC design to highlight the key issues, chal-
          lenges, and status quo in BSC design.


          2 Structure of BSC
          BSC consists of three basic stages, including biomass production, biomass
          conversion and biofuel production, and distribution to customers. This sec-
          tion briefly discusses the major features and technology options in each stage
          of BSC.

          2.1 Biomass production

          Biomass production includes activities related to the cultivation and harvest
          of biomass, transportation and storage, and preprocessing. The first three
          activities are included in almost all BSC design cases, while preprocessing
          is optional. The common types of preprocessing include torrefaction and
          pelletization, and they have been explored in different BSC design cases
          (Bergman and Kiel, 2005; Pirraglia et al., 2013; Lamers et al., 2015; Kenney
          et al., 2013). Previous studies showed that adopting preprocessing sites in
          BSC may improve the logistic stability, feedstock quality, and biorefinery
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