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Phenolic Substances fr om Olives & Olive Mill Pr oducts     399

                   Few studies have been done on the phenol’s evolution during
               storage and cooking of virgin olive oil. During frying, olive antioxi-
               dants degrade with different ratios: tocopherols degrade before the
               hydroxytyrosol, which degrades before tyrosol (Pellegrini et al. 2001).
               In optimal storage conditions, in a dark and cool room, total phenols
               and hydroxytyrosol decrease significantly in relationship with the
               time (Cinquanta et al. 1997).
                   Olive polyphenols, especially oleuropein and hydroxytyrosol,
               have been intensively studied regarding their effect on human health
               and their medicinal potential. Although most studies have been done
               in vitro, some statistical studies on human populations confirm the
               benefit of olive oil (Hill and Giacosa 1992). Higher virgin olive oil
               consumption is associated with a lower incidence of coronary heart
               disease and the risk of breast, prostate, and colon cancers (Tuck and
               Hayball 2002).
                   Finally, potential nutraceutical properties of olive polyphenols
               are synthesized in Table 14.2.



           Cytostatic and cytotoxic activity against   Owen et al. 2000; Saenz et al.
           tumoral cells                     1998
           Hypocholesterolaemic effect       De Pasquale et al. 1991
           Increase resistance of LDLs to oxidation  Auroma et al. 1998; Visioli et al.
                                             1995; Visioli et al. 2001; Salami
                                             et al. 1995; Fito et al. 2000
           Scavenging peroxy radicals, hydroxy   Visioli et al. 1998; Visioli and
           radicals and superoxide anions    Galli 1999
           Hypoglycaemic effect and antidiabetic   Trovato et al. 1993
           activity
           Inhibition of platelet aggregation   Petroni et al. 1995
           Reduction of formation of proinflammatory  De La Puerta et al. 1999;
           molecules thromboxane B  and leukotriene  Martinez-Domingues et al. 2001
                               2
           B  by activated human leukocytes
            4
           Antioxidant effects in cellular and animal  Manna et al. 1997; Speroni et al.
           models                            1998
           Prevention of passive smoking oxidative   Visioli et al. 2000
           stress
           Antimicrobial activity against many   Juven and Henis 1970; Fleming
           pathogenic microorganisms, including   et al. 1973; Bisognano et al.
           bacteria, fungi, viruses, and parasitics,    1999
           and protozoans

          TABLE 14.2  Some Potential Nutritional Properties Ascribed to Phenolic
          Substances Present in Olives and Related Olive Mill Products
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