Page 242 - Chiral Separation Techniques

220 9 Modeling and Simulation in SMB for Chiral Purification

set up, and at the same time enhancing a high throughput of drug material [11]. How-
ever, the use of SMB technology in the pharmaceutical industry is not limited to lab-
oratory tests. Its use at production scale is an alternative to, until now, leading tech-
niques such as enantioselective synthesis or diastereoisomeric crystallization. In the
past, large-scale chromatographic separations were limited mainly due to the high
cost of the adsorbent, the high dilution of products, and the large amounts of mobile
phase needed. With the introduction of the SMB technology, large-scale separations
can now be carried out under cost-effective conditions.

Fig. 9-1. Scheme of a true moving bed (TMB).