Page 7 - Chiral Separation Techniques

Chiral Separation Techniques: A Practical Approach, Second, completely revised and updated edition
Edited by G. Subramanian
Copyright © 2001 Wiley-VCH Verlag GmbH
ISBNs: 3-527-29875-4 (Hardcover); 3-527-60036-1 (Electronic)

Contents

1 Techniques in Preparative Chiral Separations 1
Ganapathy Subramanian

1.1 Introduction 1
1.2 Crystallization Techniques 2
1.3 Chromatographic Techniques 3
1.3.1 Liquid Chromatography 3
1.3.1.1 High Pressure Liquid Chromatography / Medium Pressure Liquid
Chromatography (HPLC/MPLC) 4
1.3.1.2 Flash Chromatography 7
1.3.1.3 Simulated Moving Bed (SMB) 7
1.3.1.4 Closed-loop Recycling with Periodic Intra-profile Injection
(CLRPIPI) 8
1.3.1.5 Countercurrent Chromatography (CCC/CPC) 8
1.3.2 Subcritical and Supercritical Fluid Chromatography 12
1.3.3 Gas Chromatography 13
1.4 Enantioselective Membranes 13
1.5 Other Methods 15
1.5.1 Chiral Extractions 15
1.5.2 Preparative Gel Electrophoresis and Thin-Layer
Chromatography 16
1.5.3 Enantioselective Distillations and Foam Flotation 17
1.6 Global Considerations 18
References 19

2 Method Development and Optimization of Enantiomeric
Separations Using Macrocyclic Glycopeptide Chiral Stationary
Phases 25
Thomas E. Beesley, J. T. Lee, Andy X. Wang

2.1 Introduction 25
2.2 Characteristics of Macrocyclic Glycopeptide CSPs 26