Page 242 - Color Atlas of Biochemistry

Endoplasmic reticulum and Golgi apparatus 233

A. Protein folding in the rER
1 Protein disulfide isomerase 5.3.4.1

Cyto- 2
plasm Peptidyl proline cis-trans-isomerase 5.2.1.8

gER
1 2
SH S S
S S S S S S
S S S SH S
SH
BiP (Chaperonin) Pro (cis) Pro (trans)
B. Chaperones and chaperonins
GroES
1

Folded Small
protein protein
1

7 ATP 7 ADP GroEL

Aggregation
hsp 60 4 2
2 3
(Chape- 7 P 7 P
ronin)

4

hsp 70 7 ADP 7 ATP
(chaperone)

Insoluble
precipitate
or degradation
3

Folded protein
Folded protein

C. Protein import in mitochondria

Signal peptide Nuclear-coded Cytoplasm
hsp 70 for mitochondrial mitochondrial protein
import

TOM Outer
complex mitochondrial
membrane

TIM Inner
complex mitochondrial
membrane
Mitochondrial
matrix
1. Peptidase 2. 3. hsp 70

Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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