Page 240 - Color Atlas of Biochemistry
P. 240
Endoplasmic reticulum and Golgi apparatus 231
A. Protein synthesis in the rough endoplasmic reticulum
1 2 3 4
mRNA
SRP
Signal
peptide
Free
ribosome
ER membrane
ER-lumen SRP receptor Translocon
5 6 7 8
GDP+P i
GTP
Post-transl.
Signal peptidase modification
B. Protein glycosylation
Protein
1 glycosyltransferase
2.4.1.119
Ribosome
Dolichol (Dol) Translocon 2 O-glycosidases 3.2.1.n
3 Glycosyltransferases
2.4.1.n
P Glucose
1
P
Asn N-acetylglucosamine
Mannose
Asn Galactose
N-acetylneuraminic
acid
H 2 O
UDP
GDP Asn
2
Dol
Precursors
Dol
Core structure Asn
P 3
Mannose-rich
P type
Dolichol diphosphate (9–23 isoprene units) Complex
type
Koolman, Color Atlas of Biochemistry, 2nd edition © 2005 Thieme
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